Cannabidiol (CBD) — what we know and what we don’t
health.harvard.edu/blog/cannabidoil-cbd-what-we-knkow-and-what-we-dont
NY Times article that gives an explanation of the possible benefits of CBD:
Simple Summary of Mitch McConnell’s Federal U.S. 2018 Farm Bill that was signed into law by the President:
Forbes Magazine Simple Summary of 2018 Federal Farm Bill
https://www.forbes.com/sites/julieweed/2018/12/19/us-farm-bill-will-make-cbd-production-legal-and-cheaper/#204fad7e47ba
Overarching Article with ~100 Research References from Peer-Reviewed Journals:
You can read interesting cited insights on disease states, and then go to cited research for more in-depth discoveries:
Russo, Ethan B. “Taming THC: Potential Cannabis Synergy and Phytocannabinoid-Terpenoid Entourage Effects.” British Journal of Pharmacology, vol. 163, no. 7, 2011, pp. 1344–1364., doi:10.1111/j.1476-5381.2011.01238.x.
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2011.01238.x
World Health Organization Report on Cannabidiol
https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly
Duration of Neurocognitive Impairment With Medical Cannabis Use: A Scoping Review
Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic paid in a medical cannabis cohort
Specific Research References from Peer-Reviewed Journals:
Marchalant Y, Brothers HM, Wenk GL. Inflammation and aging: Can endocannabinoids help? Biomedicine & Pharmacotherapy. 2008;62(4):212-217. doi:10.1016/j.biopha.2008.02.004.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408719/
Panikashvili D, Simeonidou C, Ben-Shabat S, et al. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature. 2001;413(6855):527-531. doi:10.1038/35097089.
https://www.researchgate.net/publication/11763987_Panikashvili_D_Simeonidou_C_Ben-Shabat_S_Hanus_L_Breuer_A_Mechoulam_R_Shohami_EAn_endogenous_cannabinoid_2-AG_is_neuroprotective_after_brain_injury_Nature_13527-531
Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (-) 9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences. 1998;95(14):8268-8273. doi:10.1073/pnas.95.14.8268.
https://www.pnas.org/content/95/14/8268
Jiang W. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. Journal of Clinical Investigation. 2005;115(11):3104-3116. doi:10.1172/jci25509.
https://www.ncbi.nlm.nih.gov/pubmed/16224541
Mckallip RJ. Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression. Molecular Pharmacology. 2006;70(3):897-908. doi:10.1124/mol.106.023937.
https://www.ncbi.nlm.nih.gov/pubmed/1675478
Mechoulam R, Parker LA, Gallily R. Cannabidiol: An Overview of Some Pharmacological Aspects. The Journal of Clinical Pharmacology. 2002;42(S1). doi:10.1002/j.1552-4604.2002.tb05998.x.
https://www.alchimiaweb.com/blogfr/wp-content/uploads/2016/06/Cannabidiol-an-overview-of-some-pharmacological-aspects-Mechoulam_et_al.pdf
Cannabidiol and (-)?9-tetrahydrocannabinol are neuroprotective antioxidants | PNAS
https://www.pnas.org/content/95/14/8268
Not peeer-reviewed but informative – How CBD Works
https://www.projectcbd.org/science/how-cbd-works
A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)
From Stony Brook Univ world-renowned cannabinoid researcher Dr. Dale Deutsch – https://www.frontiersin.org/articles/10.3389/fphar.2016.00370/full